CCDC106

Across TCGA patient cohorts, CCDC106 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCDC106-associated genes across cancer lineages are Notch1, VHL, and 14-3-3_beta. Each is linked with CCDC106 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCDC106-to-partner and partner-to-CCDC106 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by CCDC106-low versus CCDC106-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC106→partner) and Y-score (partner→CCDC106) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.230	+1.807	<.001	.027	3	2
UCEC	VHL →	-1.129	-4.087	<.001	<.001	3	2
UCEC	14-3-3_beta →	-0.107	-3.143	.010	.018	3	1
UCEC	A-Raf_pS299 →	-0.153	-2.321	.001	.006	3	1
UCEC	JNK_pT183_Y185 →	-0.180	-1.794	.009	.027	3	1
UCEC	Ku80 →	+0.272	+3.013	.005	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

Notch1 by CCDC106 expression — UCEC

Explore this box plot interactively →