CCDC106

Across TCGA pan-cancer cohorts, CCDC106 RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of CCDC106’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where CCDC106 RNA is repressed in tumor relative to normal tissue. In most cancer types CCDC106 is over-expressed in tumor, although a few such as KICH and COAD show the opposite, repressed pattern.

KICH, BRCA, and COAD are the cancer types where CCDC106 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CCDC106 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Male	All	−1.625	<.001	10	view →
BRCA	All	III,IV	+0.455	.001	6	view →
COAD	All	All	−0.534	.001	5	view →
READ	Female	All	−1.266	.029	2	view →
HNSC	Female	IV	−0.830	.042	2	view →
THCA	All	All	+0.193	.012	2	view →
BLCA	Male	IV	−1.390	.049	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

CCDC106–KICH

Open the KICH breakdown →