CCDC106

Across TCGA cell cohorts, CCDC106 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CCDC106-associated genes across cancer lineages are PRKACG, C16orf90, and C6orf118. Each is linked with CCDC106 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCDC106-to-partner and partner-to-CCDC106 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRKACG grouped by CCDC106-low versus CCDC106-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC106→partner) and Y-score (partner→CCDC106) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	PRKACG →	+0.006	+5.087	<.001	.004	3	1
URINARY_TRACT	C16orf90 →	+0.023	+5.087	<.001	.004	3	1
LARGE_INTESTINE	C6orf118 →	+0.175	+3.793	<.001	.007	3	1
LARGE_INTESTINE	ITGAD →	+0.014	+4.510	<.001	.001	3	1
LARGE_INTESTINE	IFNW1 →	+0.009	+4.054	.005	.004	3	1
LARGE_INTESTINE	FCGR3A →	+0.211	+4.347	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

PRKACG by CCDC106 expression — URINARY_TRACT

Explore this box plot interactively →