CCDC105

Across TCGA cell cohorts, CCDC105 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CCDC105-associated genes across cancer lineages are LECT2, KRTAP4-11, and PRR23C. Each is linked with CCDC105 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCDC105-to-partner and partner-to-CCDC105 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LECT2 grouped by CCDC105-low versus CCDC105-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC105→partner) and Y-score (partner→CCDC105) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	LECT2 →	+0.186	+4.922	<.001	.009	3	1
BLOOD_Leukemia	KRTAP4-11 →	+0.022	+5.539	<.001	.003	3	1
BLOOD_Leukemia	PRR23C →	+0.006	+6.569	<.001	<.001	3	1
LARGE_INTESTINE	MSGN1 →	+0.100	+3.930	<.001	.003	3	1
LARGE_INTESTINE	OR2B2 →	+0.030	+4.347	.003	.001	3	1
LARGE_INTESTINE	C14orf180 →	+0.204	+4.155	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

LECT2 by CCDC105 expression — BLOOD_Leukemia

Explore this box plot interactively →