CCAR1

Across TCGA cell cohorts, CCAR1 mutation is significantly associated with the RNA expression of many other genes, with 388 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CCAR1-associated genes across cancer lineages are GML, DMRTB1, and KRT9. Each is linked with CCAR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCAR1-to-partner and partner-to-CCAR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GML grouped by CCAR1-low versus CCAR1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCAR1→partner) and Y-score (partner→CCAR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GML →	+0.080	+3.567	<.001	.003	3	2
BLOOD_Lymphoma	DMRTB1 →	+0.031	+4.714	<.001	.002	3	1
BLOOD_Lymphoma	KRT9 →	+0.055	+4.191	<.001	.007	3	1
BLOOD_Lymphoma	ZNF804B →	+0.013	+4.350	<.001	.005	3	1
BLOOD_Lymphoma	TFDP3 →	+0.257	+4.523	<.001	.004	3	1
BLOOD_Lymphoma	OR4N4 →	+0.071	+4.191	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 388 associations by consensus.

GML by CCAR1 expression — BLOOD_Leukemia

Explore this box plot interactively →