CCAR1

Across TCGA pan-cancer cohorts, CCAR1 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of CCAR1’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where CCAR1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CCAR1 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

BLCA, STAD, and HNSC are the cancer types where CCAR1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CCAR1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Male	III,IV	+0.744	<.001	11	view →
STAD	Male	II,III,IV	+0.975	<.001	10	view →
HNSC	All	III,IV	+0.706	<.001	10	view →
LIHC	Male	II,III,IV	+1.306	<.001	9	view →
LUAD	Male	II,III,IV	+0.916	<.001	9	view →
LUSC	Female	All	+0.791	<.001	8	view →
THCA	All	All	−0.301	.001	7	view →
BRCA	All	II,III,IV	+0.604	<.001	6	view →
UCEC	All	All	+0.565	.003	6	view →
CHOL	Male	All	+2.488	<.001	5	view →
KICH	Female	All	−1.111	<.001	5	view →
READ	All	III,IV	+1.120	.004	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

CCAR1–BLCA

Open the BLCA breakdown →