CC2D2A

Across TCGA patient cohorts, CC2D2A mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CC2D2A-associated genes across cancer lineages are JNK_pT183_Y185, C-Raf, and p38-MAPK_pT180_Y182. Each is linked with CC2D2A in more than 2 cancer types. Because this analysis shows association rather than direction, both CC2D2A-to-partner and partner-to-CC2D2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by CC2D2A-low versus CC2D2A-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CC2D2A→partner) and Y-score (partner→CC2D2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	JNK_pT183_Y185 →	-0.236	-2.691	.025	.006	3	3
UCEC	C-Raf →	+0.164	+1.947	<.001	<.001	3	3
UCEC	p38-MAPK_pT180_Y182 →	-0.306	-1.678	.011	.019	3	3
UCEC	FOXO3a_pS318_S321 →	-0.082	-1.231	.014	.012	3	2
UCEC	p27_pT198 →	+0.069	+1.678	.017	.019	3	2
UCEC	PCNA →	+0.127	+1.064	.029	.043	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

JNK_pT183_Y185 by CC2D2A expression — COAD

Explore this box plot interactively →