CC2D1B

Across TCGA patient cohorts, CC2D1B mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CC2D1B-associated genes across cancer lineages are MEK1, eEF2, and EGFR_pY1068. Each is linked with CC2D1B in more than 2 cancer types. Because this analysis shows association rather than direction, both CC2D1B-to-partner and partner-to-CC2D1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by CC2D1B-low versus CC2D1B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CC2D1B→partner) and Y-score (partner→CC2D1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.490	+3.087	<.001	<.001	3	3
UCEC	eEF2 →	+0.338	+2.584	.008	.010	3	2
UCEC	EGFR_pY1068 →	-0.283	-2.807	.001	.003	3	2
UCEC	INPP4B →	-0.246	-2.115	.034	.016	3	2
UCEC	Lck →	+0.162	+1.925	.024	.005	3	2
UCEC	PARP_cleaved →	-0.263	-2.807	.017	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

MEK1 by CC2D1B expression — UCEC

Explore this box plot interactively →