CC2D1B

Across TCGA pan-cancer cohorts, CC2D1B RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of CC2D1B’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where CC2D1B RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CC2D1B is over-expressed in tumor, although a few such as KICH and LUSC show the opposite, repressed pattern.

HNSC, LIHC, and BLCA are the cancer types where CC2D1B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CC2D1B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+0.758	<.001	11	view →
LIHC	Female	II,III,IV	+1.124	<.001	9	view →
BLCA	All	III,IV	+0.539	.001	9	view →
STAD	All	II,III,IV	+0.722	<.001	8	view →
KICH	Female	All	−0.814	<.001	7	view →
KIRP	All	IV	+0.582	<.001	7	view →
UCEC	All	III,IV	+0.527	.009	6	view →
CHOL	All	All	+1.928	<.001	5	view →
KIRC	Female	All	+0.278	.006	4	view →
LUSC	Male	All	−0.286	.003	3	view →
ESCA	All	All	+0.550	.003	2	view →
COAD	Female	II,III,IV	−0.195	.032	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

CC2D1B–HNSC

Open the HNSC breakdown →