CC2D1B

Across TCGA cell cohorts, CC2D1B mutation is significantly associated with the RNA expression of many other genes, with 336 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CC2D1B-associated genes across cancer lineages are KRT71, DTHD1, and SLC22A6. Each is linked with CC2D1B in more than 1 cancer types. Because this analysis shows association rather than direction, both CC2D1B-to-partner and partner-to-CC2D1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRT71 grouped by CC2D1B-low versus CC2D1B-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CC2D1B→partner) and Y-score (partner→CC2D1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	KRT71 →	+0.006	+5.369	<.001	.004	3	1
SOFT_TISSUE	DTHD1 →	+0.006	+4.930	<.001	.008	3	1
SOFT_TISSUE	SLC22A6 →	+0.025	+4.930	<.001	.008	3	1
SOFT_TISSUE	DEFA3 →	+0.155	+4.930	<.001	.008	3	1
LARGE_INTESTINE	JOSD1 →	+0.518	+3.364	.008	.002	3	1
LARGE_INTESTINE	L3MBTL2 →	+0.721	+3.169	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 336 associations by consensus.

KRT71 by CC2D1B expression — SOFT_TISSUE

Explore this box plot interactively →