CC2D1A

Across TCGA pan-cancer cohorts, CC2D1A mass-spec protein is linked to patient survival in 8 of 34 cancer types, making it a survival-associated CC2D1A data layer compared with 30 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher CC2D1A mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated CC2D1A expression acts as an unfavorable survival marker, although some lineages such as PDAC and LUAD show a favorable association.

PDAC, LUAD, and HNSC are the cancer types where CC2D1A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Quartile	All	0.895	0.683	.003	39	view →
LUAD	OS	Tertile	III,IV	0.770	0.317	.002	28	view →
HNSC	DFS	Median	III,IV	0.431	0.785	<.001	25	view →
CCRCC	OS	Quartile	II,III,IV	0.920	0.552	.005	13	view →
UCEC	OS	Quartile	All	1.000	0.868	.018	10	view →
LSCC	DFS	Median	All	0.902	0.469	.010	9	view →
GBM	OS	Median	All	0.662	0.863	.002	7	view →
OV	DFS	Tertile	All	0.634	1.000	.047	4	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

CC2D1A–PDAC (DFS)

Open the PDAC breakdown →