CC2D1A

Across TCGA patient cohorts, CC2D1A mutation is significantly associated with the total protein of many other genes, with 55 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CC2D1A-associated genes across cancer lineages are Caspase-7-cleavedD198, Ku80, and Notch1. Each is linked with CC2D1A in more than 2 cancer types. Because this analysis shows association rather than direction, both CC2D1A-to-partner and partner-to-CC2D1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by CC2D1A-low versus CC2D1A-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CC2D1A→partner) and Y-score (partner→CC2D1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+0.951	+2.593	.004	.006	3	3
UCEC	Ku80 →	+0.179	+1.150	.015	.028	3	2
UCEC	Notch1 →	+0.089	+1.887	.043	.029	3	2
UCEC	p62 Lck ligand →	+0.244	+1.687	.017	.013	3	2
UCEC	PCNA →	+0.159	+1.584	.019	.005	3	2
COAD	IGFBP2 →	-0.768	-3.000	.008	.034	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 55 associations by consensus.

Caspase-7-cleavedD198 by CC2D1A expression — COAD

Explore this box plot interactively →