CC2D1A

Across TCGA cell cohorts, CC2D1A mutation is significantly associated with the RNA expression of many other genes, with 54 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CC2D1A-associated genes across cancer lineages are NPVF, DEFB124, and PRRG3. Each is linked with CC2D1A in more than 1 cancer types. Because this analysis shows association rather than direction, both CC2D1A-to-partner and partner-to-CC2D1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NPVF grouped by CC2D1A-low versus CC2D1A-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CC2D1A→partner) and Y-score (partner→CC2D1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	NPVF →	+0.029	+4.108	.002	.005	3	1
LUNG_NSCLC_LUSC	DEFB124 →	+0.187	+4.108	<.001	.005	3	1
UPPER_AERODIGESTIVE_TRACT	PRRG3 →	+0.249	+4.209	<.001	.006	3	1
LARGE_INTESTINE	CUEDC2 →	+0.735	+3.064	<.001	.009	2	2
LARGE_INTESTINE	ARL1 →	+0.507	+3.064	.007	.009	3	1
LARGE_INTESTINE	TEX101 →	+0.203	+3.708	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 54 associations by consensus.

NPVF by CC2D1A expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →