CBX7

Across TCGA patient cohorts, CBX7 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CBX7-associated genes across cancer lineages are A-Raf_pS299, MEK1, and Notch1. Each is linked with CBX7 in more than 1 cancer types. Because this analysis shows association rather than direction, both CBX7-to-partner and partner-to-CBX7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by CBX7-low versus CBX7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CBX7→partner) and Y-score (partner→CBX7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.115	-3.000	.033	.036	3	1
UCEC	MEK1 →	+0.347	+3.169	.035	.019	3	1
UCEC	Notch1 →	+0.183	+2.700	.004	.006	3	1
UCEC	Annexin-1 →	+0.807	+3.341	<.001	.005	3	1
UCEC	STAT3_pY705 →	-0.398	-3.321	<.001	.009	3	1
UCEC	YAP_pS127 →	+0.341	+2.000	.019	.032	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

A-Raf_pS299 by CBX7 expression — UCEC

Explore this box plot interactively →