CBX7

Across TCGA pan-cancer cohorts, CBX7 RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of CBX7’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where CBX7 RNA is repressed in tumor relative to normal tissue. In most cancer types CBX7 is over-expressed in tumor, although a few such as BLCA and KIRP show the opposite, repressed pattern.

BLCA, KIRP, and COAD are the cancer types where CBX7 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CBX7 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Male	IV	−4.107	<.001	11	view →
KIRP	Male	III,IV	−1.723	<.001	11	view →
COAD	All	III,IV	−1.403	<.001	11	view →
KICH	Male	All	−1.534	<.001	10	view →
LUAD	Female	III,IV	−1.922	<.001	9	view →
THCA	Female	All	−0.500	<.001	9	view →
LUSC	Male	II,III,IV	−1.736	<.001	8	view →
READ	All	All	−1.799	.001	7	view →
HNSC	Male	All	−0.895	<.001	7	view →
LIHC	All	II,III,IV	+0.791	<.001	7	view →
UCEC	All	All	−3.647	<.001	6	view →
BRCA	All	II,III,IV	−1.735	<.001	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

CBX7–BLCA

Open the BLCA breakdown →