CBX6

Across TCGA pan-cancer cohorts, CBX6 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated CBX6 data layer compared with 23 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher CBX6 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated CBX6 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LUAD show a favorable association.

CCRCC, LUAD, and HNSC are the cancer types where CBX6 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Tertile	All	1.000	0.618	.022	12	view →
LUAD	DFS	Tertile	All	0.828	0.469	.010	8	view →
HNSC	OS	Tertile	IV	0.913	0.687	.022	5	view →
GBM	DFS	Median	All	0.527	0.242	.006	5	view →
LSCC	OS	Median	II,III,IV	0.882	1.000	.016	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

CBX6–CCRCC (OS)

Open the CCRCC breakdown →