CBX5

Across TCGA pan-cancer cohorts, CBX5 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated CBX5 data layer compared with 27 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher CBX5 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated CBX5 expression acts as an unfavorable survival marker, although some lineages such as PDAC and LUAD show a favorable association.

CCRCC, PDAC, and LUAD are the cancer types where CBX5 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	III,IV	0.796	1.000	.007	18	view →
PDAC	DFS	Tertile	All	0.817	0.703	.014	5	view →
LUAD	OS	Median	II,III,IV	0.911	0.434	.010	5	view →
UCEC	DFS	Median	II,III,IV	0.555	0.870	.049	4	view →
HNSC	OS	Median	All	0.806	0.907	.023	1	view →
LSCC	DFS	Median	II,III,IV	1.000	0.571	.030	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

CBX5–CCRCC (DFS)

Open the CCRCC breakdown →