CBX4

Across TCGA patient cohorts, CBX4 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CBX4-associated genes across cancer lineages are ATM, eEF2, and Lck. Each is linked with CBX4 in more than 2 cancer types. Because this analysis shows association rather than direction, both CBX4-to-partner and partner-to-CBX4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by CBX4-low versus CBX4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CBX4→partner) and Y-score (partner→CBX4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.402	-1.906	.027	.016	3	3
UCEC	eEF2 →	+0.306	+3.169	.033	.018	3	1
UCEC	Lck →	+0.288	+3.087	<.001	<.001	3	1
UCEC	MEK1 →	+0.431	+2.700	.003	.006	3	1
UCEC	mTOR_pS2448 →	-0.134	-3.439	.025	.005	3	1
UCEC	NF2 →	+0.212	+2.321	.014	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

ATM by CBX4 expression — UCEC

Explore this box plot interactively →