CBX4

Across TCGA cell cohorts, CBX4 mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CBX4-associated genes across cancer lineages are SPINT4, NXNL1, and OR6M1. Each is linked with CBX4 in more than 1 cancer types. Because this analysis shows association rather than direction, both CBX4-to-partner and partner-to-CBX4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPINT4 grouped by CBX4-low versus CBX4-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CBX4→partner) and Y-score (partner→CBX4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	SPINT4 →	+0.058	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	NXNL1 →	+0.024	+5.228	.004	.005	3	1
LUNG_NSCLC_LUAD	OR6M1 →	+0.058	+5.228	<.001	.005	3	1
BLOOD_Leukemia	HAND1 →	+0.020	+3.623	<.001	.007	3	1
BLOOD_Leukemia	SLC38A11 →	+0.097	+3.852	<.001	.007	3	1
BLOOD_Leukemia	DEFB125 →	+0.023	+3.475	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

SPINT4 by CBX4 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →