CBX2

Across TCGA cell cohorts, CBX2 mutation is significantly associated with the RNA expression of many other genes, with 89 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CBX2-associated genes across cancer lineages are REG1B, ASZ1, and KHDC3L. Each is linked with CBX2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CBX2-to-partner and partner-to-CBX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, REG1B grouped by CBX2-low versus CBX2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CBX2→partner) and Y-score (partner→CBX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	REG1B →	+2.060	+3.518	<.001	.001	3	2
BLOOD_Leukemia	ASZ1 →	+0.086	+3.567	.005	.003	3	2
BLOOD_Leukemia	KHDC3L →	+0.277	+4.096	<.001	.001	3	2
OVARY	OR12D2 →	+0.058	+4.700	<.001	.002	3	1
LUNG_NSCLC_LUAD	CRP →	+0.321	+2.980	<.001	.007	3	1
LUNG_NSCLC_LUAD	FAM170A →	+0.176	+4.225	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 89 associations by consensus.

REG1B by CBX2 expression — LARGE_INTESTINE

Explore this box plot interactively →