CBX1

Across TCGA patient cohorts, CBX1 mutation is significantly associated with the RNA expression of many other genes, with 1,053 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CBX1-associated genes across cancer lineages are RN7SL863P, RNU6-492P, and RNU4-26P. Each is linked with CBX1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CBX1-to-partner and partner-to-CBX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL863P grouped by CBX1-low versus CBX1-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CBX1→partner) and Y-score (partner→CBX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RN7SL863P →	+0.128	+7.954	<.001	.008	3	2
HNSC	RNU6-492P →	+0.478	+7.954	<.001	.008	3	1
HNSC	RNU4-26P →	+0.268	+7.954	<.001	.008	3	1
UCEC	YTHDF3-AS1 →	+0.436	+2.724	.009	.003	3	1
UCEC	HMGB1P50 →	+0.111	+1.583	.005	.009	3	1
UCEC	LINC02550 →	-0.446	-1.967	.006	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,053 associations by consensus.

RN7SL863P by CBX1 expression — HNSC

Explore this box plot interactively →