CBS

Across TCGA patient cohorts, CBS RNA expression is significantly associated with the protein abundance of many other proteins, with 15,313 significant associations in total. GBM shows the largest number of these associations.

The most reproducible CBS-associated proteins across cancer lineages are SMC4, NCAPG, and SMC2. Each is linked with CBS in more than 6 cancer types. Because this analysis shows association rather than direction, both CBS-to-partner and partner-to-CBS results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CBS versus SMC4 in UCEC, with a Pearson correlation of 0.37.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (CBS→partner) and Y-score (partner→CBS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SMC4 →	+0.539	+0.577	<.001	<.001	3	7
LSCC	NCAPG →	+0.455	+0.513	<.001	<.001	3	6
BRCA	SMC2 →	+0.576	+0.525	<.001	.007	2	7
HNSC	RIF1 →	+0.505	+0.526	<.001	<.001	3	6
LSCC	MDC1_S882 →	+0.839	+0.709	<.001	<.001	3	6
OV	FANCI →	+0.734	+0.714	.004	.006	2	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,313 associations by consensus.

CBS vs SMC4 — UCEC

Explore this scatter interactively →