CBS

Across TCGA patient cohorts, CBS mutation is significantly associated with the RNA expression of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CBS-associated genes across cancer lineages are RNA5SP109, RPS29P26, and MIR6793. Each is linked with CBS in more than 1 cancer types. Because this analysis shows association rather than direction, both CBS-to-partner and partner-to-CBS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP109 grouped by CBS-low versus CBS-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CBS→partner) and Y-score (partner→CBS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP109 →	+0.357	+4.722	<.001	.004	3	2
SKCM	RPS29P26 →	+0.266	+7.816	<.001	.008	3	1
UCEC	MIR6793 →	+0.892	+3.706	.005	.007	3	1
UCEC	MIR6780B →	+0.548	+3.889	<.001	.004	3	1
UCEC	MIR6779 →	+0.751	+4.420	<.001	.001	3	1
UCEC	IGHD3-16 →	+1.776	+4.417	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

RNA5SP109 by CBS expression — UCEC

Explore this box plot interactively →