CBLN3

Across TCGA patient cohorts, CBLN3 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CBLN3-associated genes across cancer lineages are p62 Lck ligand, PDK1_pS241, and Caspase-7-cleavedD198. Each is linked with CBLN3 in more than 1 cancer types. Because this analysis shows association rather than direction, both CBLN3-to-partner and partner-to-CBLN3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by CBLN3-low versus CBLN3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CBLN3→partner) and Y-score (partner→CBLN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.462	+3.321	.006	.010	3	1
UCEC	PDK1_pS241 →	+0.220	+3.169	.014	.019	3	1
UCEC	Caspase-7-cleavedD198 →	+1.458	+3.019	<.001	.019	3	1
UCEC	Caspase-8 →	-0.300	-2.973	.023	.035	3	1
UCEC	EGFR_pY1068 →	-0.319	-3.321	.015	.010	2	1
UCEC	Cyclin-B1 →	+0.683	+3.321	.020	.010	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

p62 Lck ligand by CBLN3 expression — UCEC

Explore this box plot interactively →