CBLN3

Across TCGA pan-cancer cohorts, CBLN3 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated CBLN3 data layer compared with 5 for mutation status.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher CBLN3 RNA is associated with better overall survival. In most high-consensus cancer types, elevated CBLN3 expression acts as an unfavorable survival marker, although some lineages such as SKCM and MESO show a favorable association.

SKCM, MESO, and KICH are the cancer types where CBLN3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	II,III,IV	0.388	0.234	<.001	110	view →
MESO	OS	Tertile	All	0.718	0.419	<.001	89	view →
KICH	OS	Median	II,III,IV	0.888	1.000	.009	64	view →
UVM	DFS	Tertile	II,III,IV	0.567	0.931	.001	53	view →
LGG	OS	Median	All	0.732	0.887	<.001	51	view →
KIRP	DFS	Median	All	0.784	0.934	<.001	32	view →
LAML	DFS	Tertile	All	0.282	0.517	.006	30	view →
HNSC	DFS	Quartile	II,III,IV	0.514	0.224	.003	26	view →
ACC	OS	Quartile	IV	0.961	0.429	.006	20	view →
BRCA	OS	Median	All	0.944	0.904	.006	16	view →
GBM	OS	Quartile	All	0.299	0.543	.005	12	view →
DLBC	DFS	Tertile	All	0.653	1.000	.010	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

CBLN3–SKCM (OS)

Open the SKCM breakdown →