CBLC

Across TCGA patient cohorts, CBLC mutation is significantly associated with the RNA expression of many other genes, with 294 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CBLC-associated genes across cancer lineages are TMEM214, TRAJ5, and BNIP3P41. Each is linked with CBLC in more than 1 cancer types. Because this analysis shows association rather than direction, both CBLC-to-partner and partner-to-CBLC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TMEM214 grouped by CBLC-low versus CBLC-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CBLC→partner) and Y-score (partner→CBLC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TMEM214 →	+0.374	+3.700	.008	.001	3	2
UCEC	TRAJ5 →	+0.853	+2.943	<.001	<.001	3	2
UCEC	BNIP3P41 →	+0.017	+4.893	<.001	.001	3	2
UCEC	SNRPGP17 →	+0.330	+2.727	<.001	<.001	3	1
UCEC	MIR6127 →	+0.245	+2.977	.002	.009	3	1
LGG	USP9YP10 →	+0.049	+7.977	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 294 associations by consensus.

TMEM214 by CBLC expression — UCEC

Explore this box plot interactively →