CBFB

Across TCGA pan-cancer cohorts, CBFB mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated CBFB data layer compared with 26 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher CBFB mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated CBFB expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

COAD, LSCC, and CCRCC are the cancer types where CBFB mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	II,III,IV	0.875	1.000	.014	78	view →
LSCC	DFS	Tertile	II,III,IV	0.669	0.958	.001	33	view →
CCRCC	OS	Tertile	All	0.685	0.960	<.001	28	view →
HNSC	DFS	Quartile	III,IV	0.452	0.837	.001	27	view →
UCEC	OS	Median	All	1.000	0.841	.002	26	view →
PDAC	OS	Median	II,III,IV	0.345	0.646	.003	14	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

CBFB–COAD (DFS)

Open the COAD breakdown →