CBFB

Across TCGA patient cohorts, CBFB RNA expression is significantly associated with the mutation status of many other genes, with 9,243 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CBFB-associated genes across cancer lineages are TP53, AHNAK2, and FLG. Each is linked with CBFB in more than 6 cancer types. Because this analysis shows association rather than direction, both CBFB-to-partner and partner-to-CBFB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TP53 grouped by CBFB-low versus CBFB-high in SKCM.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CBFB→partner) and Y-score (partner→CBFB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	TP53 →	+1.491	+0.414	<.001	<.001	3	7
STAD	AHNAK2 →	+2.518	+0.351	<.001	.001	3	5
LGG	FLG →	+3.601	+0.507	.001	.001	3	4
STAD	TTN →	+0.817	+0.353	<.001	<.001	3	4
STAD	KMT2D →	+2.923	+0.415	<.001	<.001	3	4
STAD	DSCAM →	+2.716	+0.353	.002	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,243 associations by consensus.

TP53 by CBFB expression — SKCM

Explore this box plot interactively →