CAVIN3

Across TCGA patient cohorts, CAVIN3 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CAVIN3-associated genes across cancer lineages are ATM, PKC-b-II_pS660, and AR. Each is linked with CAVIN3 in more than 1 cancer types. Because this analysis shows association rather than direction, both CAVIN3-to-partner and partner-to-CAVIN3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by CAVIN3-low versus CAVIN3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CAVIN3→partner) and Y-score (partner→CAVIN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.583	-3.000	.026	.037	3	2
UCEC	PKC-b-II_pS660 →	-0.364	-3.000	.022	.036	3	1
UCEC	AR →	-0.466	-3.000	.031	.037	3	1
UCEC	p62 Lck ligand →	+0.545	+2.817	.003	.036	2	1
UCEC	p70-S6K_pT389 →	-0.219	-3.000	.046	.037	2	1
UCEC	PCNA →	+0.322	+3.000	.010	.037	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

ATM by CAVIN3 expression — UCEC

Explore this box plot interactively →