CAVIN3

Across TCGA pan-cancer cohorts, CAVIN3 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of CAVIN3’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where CAVIN3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CAVIN3 is over-expressed in tumor, although a few such as BLCA and KICH show the opposite, repressed pattern.

KIRC, HNSC, and BLCA are the cancer types where CAVIN3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CAVIN3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	IV	+2.454	<.001	12	view →
HNSC	Female	IV	+2.420	<.001	12	view →
BLCA	Male	III,IV	−2.068	.001	8	view →
LIHC	Female	All	+1.383	<.001	8	view →
KICH	Male	II,III,IV	−1.848	<.001	7	view →
UCEC	All	All	−2.335	<.001	6	view →
BRCA	All	II,III,IV	−0.686	<.001	6	view →
CHOL	All	All	+2.684	<.001	5	view →
KIRP	Male	All	+0.830	.003	5	view →
LUAD	All	All	−0.594	<.001	5	view →
LUSC	All	All	−0.553	.003	3	view →
ESCA	Male	All	+1.386	.016	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

CAVIN3–KIRC

Open the KIRC breakdown →