CAVIN1

Across TCGA patient cohorts, CAVIN1 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CAVIN1-associated genes across cancer lineages are Caspase-7-cleavedD198, MEK1, and eEF2. Each is linked with CAVIN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CAVIN1-to-partner and partner-to-CAVIN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by CAVIN1-low versus CAVIN1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CAVIN1→partner) and Y-score (partner→CAVIN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.503	+2.815	<.001	.036	3	2
UCEC	MEK1 →	+0.591	+3.169	.003	.020	2	2
UCEC	eEF2 →	+0.411	+3.169	.036	.020	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.625	-3.156	.011	.020	3	1
UCEC	PDCD4 →	-0.707	-3.169	.006	.020	2	2
UCEC	STAT3_pY705 →	-0.408	-3.169	.004	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

Caspase-7-cleavedD198 by CAVIN1 expression — COAD

Explore this box plot interactively →