CATSPERD

Across TCGA patient cohorts, CATSPERD mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CATSPERD-associated genes across cancer lineages are A-Raf_pS299, EGFR_pY1068, and MSH2. Each is linked with CATSPERD in more than 2 cancer types. Because this analysis shows association rather than direction, both CATSPERD-to-partner and partner-to-CATSPERD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by CATSPERD-low versus CATSPERD-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CATSPERD→partner) and Y-score (partner→CATSPERD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.081	-2.321	.043	.005	3	3
COAD	EGFR_pY1068 →	-0.373	-2.987	.008	.035	3	2
COAD	MSH2 →	-0.319	-2.450	.001	.020	3	2
COAD	p90 RSK_pT359_S363 →	-0.160	-2.450	.039	.020	3	2
UCEC	Rab25 →	-0.338	-3.584	.002	.002	3	2
UCEC	VHL →	-1.055	-2.201	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

A-Raf_pS299 by CATSPERD expression — UCEC

Explore this box plot interactively →