CATSPERD

Across TCGA pan-cancer cohorts, CATSPERD RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of CATSPERD’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where CATSPERD RNA is repressed in tumor relative to normal tissue. In most cancer types CATSPERD is over-expressed in tumor, although a few such as LUSC and LUAD show the opposite, repressed pattern.

LUSC, LUAD, and THCA are the cancer types where CATSPERD tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CATSPERD RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	Female	All	−1.531	<.001	8	view →
LUAD	Female	II,III,IV	−1.280	<.001	8	view →
THCA	All	All	−0.028	.012	3	view →
UCEC	All	All	−1.060	.031	2	view →
CHOL	All	II,III,IV	+0.130	.022	2	view →
KIRC	Female	IV	−0.026	.033	1	view →
LIHC	All	All	+0.014	.036	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

CATSPERD–LUSC

Open the LUSC breakdown →