CAT

Across TCGA patient cohorts, CAT mutation is significantly associated with the RNA expression of many other genes, with 1,314 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CAT-associated genes across cancer lineages are MIR4507, USP9YP10, and CENPH. Each is linked with CAT in more than 1 cancer types. Because this analysis shows association rather than direction, both CAT-to-partner and partner-to-CAT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4507 grouped by CAT-low versus CAT-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CAT→partner) and Y-score (partner→CAT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	MIR4507 →	+0.562	+3.705	<.001	.008	3	2
LGG	USP9YP10 →	+0.049	+7.977	<.001	.007	3	2
UCEC	CENPH →	+0.623	+2.332	.002	.003	3	2
UCEC	C16orf87 →	+0.534	+2.364	.001	.003	3	2
UCEC	ATMIN →	+0.561	+3.032	<.001	<.001	3	2
UCEC	GLOD4 →	+0.484	+3.010	.003	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,314 associations by consensus.

MIR4507 by CAT expression — CESC

Explore this box plot interactively →