CASZ1

Across TCGA cell cohorts, CASZ1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,196 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible CASZ1-associated GO terms across cancer lineages are Negative regulation of mRNA catabolic process, Negative regulation of Arp2/3 complex-mediated actin nucleation, and Regulation of chromatin organization. Each is linked with CASZ1 in more than 12 cancer types. Because this analysis shows association rather than direction, both CASZ1-to-partner and partner-to-CASZ1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of mRNA catabolic process grouped by CASZ1-low versus CASZ1-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CASZ1→partner) and Y-score (partner→CASZ1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Negative regulation of mRNA catabolic process →	+0.063	+1.162	.005	.003	3	13
STOMACH	Negative regulation of Arp2/3 complex-mediated actin nucleation →	+0.203	+1.646	<.001	<.001	3	11
BLOOD_Leukemia	Regulation of chromatin organization →	+0.072	+0.781	<.001	<.001	3	11
SOFT_TISSUE	Negative regulation of actin nucleation →	+0.145	+1.136	<.001	<.001	2	10
STOMACH	Copper ion export →	-0.182	-1.339	<.001	<.001	3	9
LARGE_INTESTINE	Regulation of syncytium formation by plasma membrane fusion →	+0.085	+1.378	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,196 associations by consensus.

Negative regulation of mRNA catabolic process by CASZ1 expression — BONE

Explore this box plot interactively →