CASZ1

Across TCGA pan-cancer cohorts, CASZ1 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of CASZ1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where CASZ1 RNA is repressed in tumor relative to normal tissue. In most cancer types CASZ1 is over-expressed in tumor, although a few such as KIRC and KIRP show the opposite, repressed pattern.

KIRC, KIRP, and THCA are the cancer types where CASZ1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CASZ1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	III,IV	−1.549	<.001	12	view →
KIRP	Male	All	−1.449	<.001	11	view →
THCA	Male	III,IV	−1.245	<.001	11	view →
LUAD	Female	II,III,IV	−1.185	<.001	8	view →
COAD	Female	II,III,IV	−0.587	<.001	8	view →
KICH	All	All	−0.701	<.001	7	view →
BRCA	All	II,III,IV	+0.545	<.001	6	view →
BLCA	All	All	−0.505	.004	6	view →
CHOL	Male	All	+2.091	<.001	5	view →
LIHC	All	All	+0.297	.001	5	view →
STAD	Female	All	−0.854	.018	3	view →
LUSC	Male	All	−0.385	.010	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

CASZ1–KIRC

Open the KIRC breakdown →