CASZ1

Across TCGA cell cohorts, CASZ1 mutation is significantly associated with the RNA expression of many other genes, with 730 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CASZ1-associated genes across cancer lineages are CTSS, PF4, and IGFL3. Each is linked with CASZ1 in more than 2 cancer types. Because this analysis shows association rather than direction, both CASZ1-to-partner and partner-to-CASZ1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CTSS grouped by CASZ1-low versus CASZ1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CASZ1→partner) and Y-score (partner→CASZ1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CTSS →	-1.847	-3.321	.002	.002	3	3
BONE	PF4 →	+0.101	+3.688	.009	.007	3	2
OESOPHAGUS	IGFL3 →	+0.418	+3.781	.003	.002	3	2
OESOPHAGUS	OTC →	+0.020	+3.273	<.001	.004	3	2
LUNG_SCLC	PYDC2 →	+0.122	+4.058	<.001	.007	3	2
UPPER_AERODIGESTIVE_TRACT	USP29 →	+0.029	+4.510	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 730 associations by consensus.

CTSS by CASZ1 expression — LARGE_INTESTINE

Explore this box plot interactively →