CASTOR3

Across TCGA patient cohorts, CASTOR3 mutation is significantly associated with the RNA expression of many other genes, with 274 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CASTOR3-associated genes across cancer lineages are RN7SKP154, RNA5SP518, and LSM3P3. Each is linked with CASTOR3 in more than 1 cancer types. Because this analysis shows association rather than direction, both CASTOR3-to-partner and partner-to-CASTOR3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SKP154 grouped by CASTOR3-low versus CASTOR3-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CASTOR3→partner) and Y-score (partner→CASTOR3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	RN7SKP154 →	+0.206	+3.984	<.001	.003	3	2
LUSC	RNA5SP518 →	+0.236	+6.924	<.001	<.001	3	2
SKCM	LSM3P3 →	+0.215	+3.719	.001	.006	3	2
LUAD	MRPS18BP2 →	+0.065	+4.554	<.001	.009	3	2
UCEC	TNPO1P2 →	+0.056	+2.621	.002	.001	3	2
SKCM	AK6P1 →	+0.055	+3.302	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 274 associations by consensus.

RN7SKP154 by CASTOR3 expression — LUSC

Explore this box plot interactively →