CASP9

Across TCGA patient cohorts, CASP9 mutation is significantly associated with the RNA expression of many other genes, with 1,478 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CASP9-associated genes across cancer lineages are SLC25A3P3, RNA5SP507, and USH2A-AS2. Each is linked with CASP9 in more than 2 cancer types. Because this analysis shows association rather than direction, both CASP9-to-partner and partner-to-CASP9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC25A3P3 grouped by CASP9-low versus CASP9-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CASP9→partner) and Y-score (partner→CASP9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	SLC25A3P3 →	+0.052	+4.812	<.001	.006	3	3
SKCM	RNA5SP507 →	+0.481	+3.992	.001	.002	3	2
SKCM	USH2A-AS2 →	+0.073	+3.302	<.001	.009	3	2
SKCM	VN1R93P →	+0.057	+3.877	<.001	.003	3	2
SKCM	PPP1R26P3 →	+0.005	+4.147	<.001	.008	3	2
SKCM	ACTG1P13 →	+0.053	+3.508	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,478 associations by consensus.

SLC25A3P3 by CASP9 expression — CESC

Explore this box plot interactively →