CASP8AP2

Across TCGA pan-cancer cohorts, CASP8AP2 mass-spec protein differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of CASP8AP2’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where CASP8AP2 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types CASP8AP2 is over-expressed in tumor, although a few such as PDAC show the opposite, repressed pattern.

LSCC and PDAC are the cancer types where CASP8AP2 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CASP8AP2 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LSCC	All	II,III,IV	+0.745	<.001	9	view →
PDAC	All	All	−0.457	.045	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 2 strongest of 2 lineages.

CASP8AP2–LSCC

Open the LSCC breakdown →