CASP8AP2

Across TCGA patient cohorts, CASP8AP2 mutation is significantly associated with the RNA expression of many other genes, with 5,851 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CASP8AP2-associated genes across cancer lineages are FAM136A, BCCIP, and MRPS15. Each is linked with CASP8AP2 in more than 4 cancer types. Because this analysis shows association rather than direction, both CASP8AP2-to-partner and partner-to-CASP8AP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM136A grouped by CASP8AP2-low versus CASP8AP2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CASP8AP2→partner) and Y-score (partner→CASP8AP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FAM136A →	+0.315	+2.019	<.001	<.001	3	5
UCEC	BCCIP →	+0.272	+2.052	.004	<.001	3	4
UCEC	MRPS15 →	+0.293	+2.157	.001	<.001	3	4
COAD	RPA2 →	+0.543	+2.169	<.001	.009	3	4
UCEC	PPP1R8 →	+0.321	+1.890	<.001	<.001	3	4
UCEC	MND1 →	+0.570	+1.700	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,851 associations by consensus.

FAM136A by CASP8AP2 expression — UCEC

Explore this box plot interactively →