CASP8AP2

Across TCGA patient cohorts, CASP8AP2 mutation is significantly associated with the total protein of many other genes, with 66 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CASP8AP2-associated genes across cancer lineages are Cyclin-B1, eEF2, and ASNS. Each is linked with CASP8AP2 in more than 4 cancer types. Because this analysis shows association rather than direction, both CASP8AP2-to-partner and partner-to-CASP8AP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by CASP8AP2-low versus CASP8AP2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CASP8AP2→partner) and Y-score (partner→CASP8AP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.604	+1.722	<.001	<.001	3	5
UCEC	eEF2 →	+0.300	+2.502	.002	.001	3	4
COAD	ASNS →	+0.638	+3.169	<.001	.017	3	4
COAD	Caspase-7-cleavedD198 →	+1.633	+3.815	<.001	<.001	3	3
UCEC	EGFR_pY1068 →	-0.253	-1.722	<.001	<.001	3	2
UCEC	ERK2 →	+0.198	+2.070	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 66 associations by consensus.

Cyclin-B1 by CASP8AP2 expression — UCEC

Explore this box plot interactively →