CASP8

Across TCGA patient cohorts, CASP8 RNA expression is significantly associated with the protein abundance of many other proteins, with 15,436 significant associations in total. GBM shows the largest number of these associations.

The most reproducible CASP8-associated proteins across cancer lineages are UBA7, NMI, and IFI35. Each is linked with CASP8 in more than 7 cancer types. Because this analysis shows association rather than direction, both CASP8-to-partner and partner-to-CASP8 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CASP8 versus UBA7 in BRCA, with a Pearson correlation of 0.39.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (CASP8→partner) and Y-score (partner→CASP8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	UBA7 →	+0.396	+0.774	<.001	<.001	3	8
BRCA	NMI →	+0.452	+0.682	<.001	<.001	3	8
OV	IFI35 →	+0.455	+0.647	<.001	<.001	3	8
GBM	PARP9 →	+0.608	+0.670	<.001	<.001	3	7
HNSC	PSMB8 →	+0.350	+0.584	<.001	<.001	3	7
BRCA	SAMD9 →	+0.435	+0.644	.002	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,436 associations by consensus.

CASP8 vs UBA7 — BRCA

Explore this scatter interactively →