CASP5

Across TCGA patient cohorts, CASP5 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CASP5-associated genes across cancer lineages are EGFR_pY1068, Rad50, and EGFR. Each is linked with CASP5 in more than 1 cancer types. Because this analysis shows association rather than direction, both CASP5-to-partner and partner-to-CASP5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by CASP5-low versus CASP5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CASP5→partner) and Y-score (partner→CASP5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.247	-2.807	.004	.003	3	2
UCEC	Rad50 →	-0.191	-2.308	.022	.033	3	2
UCEC	EGFR →	-0.157	-2.459	.004	.019	3	1
UCEC	eIF4E →	+0.185	+2.070	.011	.001	3	1
UCEC	A-Raf_pS299 →	-0.118	-1.584	.004	.034	3	1
UCEC	FoxM1 →	+0.283	+2.070	.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

EGFR_pY1068 by CASP5 expression — UCEC

Explore this box plot interactively →