CASP5

Across TCGA pan-cancer cohorts, CASP5 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated CASP5 data layer compared with 5 for mutation status.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher CASP5 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated CASP5 expression acts as an unfavorable survival marker, although some lineages such as SKCM and OV show a favorable association.

KIRP, SCLC, and SKCM are the cancer types where CASP5 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Tertile	All	0.748	0.933	<.001	88	view →
SCLC	OS	Tertile	II,III,IV	0.164	0.819	<.001	84	view →
SKCM	OS	Median	All	0.432	0.251	<.001	78	view →
KIRC	DFS	Tertile	All	0.737	0.891	<.001	67	view →
KICH	OS	Median	III,IV	0.529	1.000	<.001	52	view →
THYM	OS	Median	All	0.744	0.960	.002	46	view →
LGG	OS	Median	All	0.363	0.536	<.001	43	view →
ESCA	OS	Median	All	0.617	1.000	.009	32	view →
UVM	OS	Tertile	All	0.420	0.835	.010	21	view →
OV	OS	Quartile	II,III,IV	0.463	0.329	.014	20	view →
STAD	OS	Median	All	0.467	0.283	.010	18	view →
CHOL	DFS	Tertile	All	0.748	0.198	.009	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

CASP5–KIRP (DFS)

Open the KIRP breakdown →