CASP5

Across TCGA cell cohorts, CASP5 mutation is significantly associated with the RNA expression of many other genes, with 20 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible CASP5-associated genes across cancer lineages are MBD3L3, DBX2, and CCER1. Each is linked with CASP5 in more than 1 cancer types. Because this analysis shows association rather than direction, both CASP5-to-partner and partner-to-CASP5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MBD3L3 grouped by CASP5-low versus CASP5-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CASP5→partner) and Y-score (partner→CASP5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	MBD3L3 →	+0.110	+5.614	<.001	.002	3	2
PANCREAS	DBX2 →	+0.006	+5.000	<.001	.006	3	1
PANCREAS	CCER1 →	+0.006	+5.614	<.001	.002	3	1
PANCREAS	OPN1MW →	+0.028	+5.000	<.001	.006	3	1
LUNG_NSCLC_LUAD	OR6M1 →	+0.058	+5.228	<.001	.005	3	1
BLOOD_Leukemia	PPP1R2C →	+0.230	+4.539	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

MBD3L3 by CASP5 expression — PANCREAS

Explore this box plot interactively →