CASP3

Across TCGA pan-cancer cohorts, CASP3 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated CASP3 data layer compared with 27 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher CASP3 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated CASP3 expression acts as an unfavorable survival marker, although some lineages such as UCEC and LUAD show a favorable association.

PDAC, UCEC, and LUAD are the cancer types where CASP3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Quartile	III,IV	0.323	1.000	.005	46	view →
UCEC	DFS	Quartile	II,III,IV	1.000	0.367	.007	24	view →
LUAD	DFS	Tertile	III,IV	0.771	0.286	.002	9	view →
HNSC	DFS	Median	II,III,IV	0.892	0.996	.003	5	view →
LSCC	DFS	Median	II,III,IV	0.668	0.861	.013	4	view →
GBM	DFS	Quartile	All	0.210	0.404	.030	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

CASP3–PDAC (DFS)

Open the PDAC breakdown →