CASP3

Across TCGA patient cohorts, CASP3 mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CASP3-associated genes across cancer lineages are Rab25, 14-3-3_beta, and EGFR_pY1068. Each is linked with CASP3 in more than 1 cancer types. Because this analysis shows association rather than direction, both CASP3-to-partner and partner-to-CASP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rab25 grouped by CASP3-low versus CASP3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CASP3→partner) and Y-score (partner→CASP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Rab25 →	-0.376	-2.999	.007	.035	3	2
UCEC	14-3-3_beta →	-0.104	-2.973	.014	.035	3	1
UCEC	EGFR_pY1068 →	-0.325	-3.584	.002	.002	3	1
UCEC	FoxM1 →	+0.224	+2.222	.041	.011	3	1
UCEC	JNK_pT183_Y185 →	-0.176	-1.687	.013	.044	3	1
UCEC	JNK2 →	+0.354	+3.710	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

Rab25 by CASP3 expression — UCEC

Explore this box plot interactively →