CASP3

Across TCGA cell cohorts, CASP3 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,419 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CASP3-associated GO terms across cancer lineages are Response to insulin-like growth factor stimulus, Swimming behavior, and Positive regulation of t-circle formation. Each is linked with CASP3 in more than 15 cancer types. Because this analysis shows association rather than direction, both CASP3-to-partner and partner-to-CASP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Response to insulin-like growth factor stimulus grouped by CASP3-low versus CASP3-high in BLOOD_Lymphoma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CASP3→partner) and Y-score (partner→CASP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	Response to insulin-like growth factor stimulus →	+0.181	+1.063	<.001	<.001	3	16
SOFT_TISSUE	Swimming behavior →	+0.134	+0.974	<.001	<.001	3	14
SKIN	Positive regulation of t-circle formation →	-0.149	-0.691	<.001	<.001	3	12
BONE	Response to staurosporine →	+0.166	+0.515	<.001	.001	3	12
BONE	Cellular response to staurosporine →	+0.166	+0.515	<.001	.001	3	12
UPPER_AERODIGESTIVE_TRACT	DNA replication, synthesis of primer →	+0.175	+1.242	<.001	<.001	2	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,419 associations by consensus.

Response to insulin-like growth factor stimulus by CASP3 expression — BLOOD_Lymphoma

Explore this box plot interactively →