Across TCGA cell cohorts, CASP12 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible CASP12-associated genes across cancer lineages are SPATA31D1, OR10G3, and TEX50. Each is linked with CASP12 in more than 1 cancer types. Because this analysis shows association rather than direction, both CASP12-to-partner and partner-to-CASP12 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CASP12→partner) and Y-score (partner→CASP12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	SPATA31D1 →	+0.843	+5.643	<.001	.002	3	2
LUNG_SCLC	OR10G3 →	+0.063	+5.643	<.001	.002	3	1
LUNG_SCLC	TEX50 →	+0.040	+5.643	<.001	.002	3	1
LUNG_SCLC	SERPINA2 →	+0.038	+5.029	<.001	.006	3	1
LUNG_SCLC	OR8K3 →	+0.016	+5.029	<.001	.006	3	1
LUNG_NSCLC_LUAD	ACTRT1 →	+0.013	+3.887	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

Exploration

CASP12 survival (RNA) · tumor vs normal (RNA) · all CASP12 data types